Transmembrane integrin bridges the extracellular and intracellular environments and is activated by focal adhesion proteins, talin and kindlin. Activated integrin engages ligands from the extracellular matrix and controls intracellular responses. In this issue of Structure, Zhu et al. (2019) describe an initial step involving recruitment of paxillin by ubiquitin-like kindlin-2 domain.

中文翻译：

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Kindlin外部连接。

跨膜整联蛋白桥接细胞外和细胞内环境，并被粘着斑蛋白，塔林和kindlin激活。活化的整联蛋白与细胞外基质的配体结合并控制细胞内反应。在本期《结构》中，Zhu等人。（2019）描述了涉及通过泛素样kindlin-2结构域募集paxillin的第一步。