Sunscreen-containing skincare products protect the skin from damage caused by sun exposure. However, many of them contain oxybenzone and/or octinoxate, which have been reported to be toxic to juvenile coral and to cause coral bleaching. Thus, there is a growing need for new sunscreen compounds that are less harmful to the environment. Here, we report an engineered biosynthetic pathway employing genes from a vertebrate and two Gram-(+) bacteria that forms novel sunscreen compounds with hybrid structures of gadusol and mycosporine-like amino acids, both of which are found in marine environments. These compounds, named gadusporines, have unique UV absorbance at 340 nm, expanding the range of mycosporine- and gadusol-based sunscreen products. The synthesis of gadusporines in Streptomyces coelicolor establishes a platform for the design and production of novel sunscreens.

中文翻译：

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Interkingdom基因混合搭配生产出新颖的防晒霜。

含防晒霜的护肤产品可保护皮肤免受日晒所造成的损害。但是，其中许多含有氧二苯甲酮和/或辛氧酸酯，据报道它们对少年珊瑚有毒，并引起珊瑚白化。因此，越来越需要对环境危害较小的新型防晒化合物。在这里，我们报告了一种工程化的生物合成途径，该途径利用了来自脊椎动物和两种革兰氏（+）细菌的基因，这些细菌形成了具有gadusol和霉菌素样氨基酸混合结构的新型防晒化合物，两者均在海洋环境中发现。这些化合物被称为gadusporines，在340 nm处具有独特的紫外线吸收率，从而扩大了基于霉菌素和gadusol的防晒产品的范围。产油链霉菌中的gadusporines的合成 为新型防晒霜的设计和生产建立了平台。