Science China Chemistry ( IF 9.6 ) Pub Date : 2019-10-30 , DOI: 10.1007/s11426-019-9616-8 Ziyue Chen , Fangling Lu , Feng Yuan , Juanjuan Sun , Linyu Du , Zhen Li , Meng Gao , Renyi Shi , Aiwen Lei
Photocatalytic decarboxylative cross-coupling which achieves the derivatization of widespread organic acids has become a hot topic in organic synthesis. As special acids, α-oxocarboxylicacids show the great potential in running decarboxylation to construct ketone derivatives. In this article, we have developed a photocatalytic decarboxylative cross-coupling of α-oxocarboxylicacids and olefins to the synthesis of diverse aryl ketones. Various alkenes and α-oxocarboxylicacids were compatible, generating the desired products in up to 90% yield. Preliminary mechanism studies suggest that a free radical pathway is involved in this process.
中文翻译:
α-氧代羧酸与烯烃的光催化脱羧偶联
实现广泛的有机酸衍生化的光催化脱羧交叉偶联已成为有机合成中的热门话题。作为特殊的酸,α-氧代羧酸显示出进行脱羧反应以构建酮衍生物的巨大潜力。在本文中,我们开发了α-氧代羧酸和烯烃的光催化脱羧交叉偶联反应,以合成各种芳基酮。各种烯烃和α-氧代羧酸相容,可以以高达90%的收率生成所需的产物。初步的机理研究表明该过程涉及自由基途径。