The coinhibitory molecule B7-H4, an important member of the B7 family, is abnormally expressed in tumors, inflammation and autoimmune diseases. B7-H4 negatively regulates T cell immune response and promotes immune escape by inhibiting the proliferation, cytokine secretion, and cell cycle of T cells. Moreover, B7-H4 plays an extremely important role in tumorigenesis and tumor development including cell proliferation, invasion, metastasis, anti-apoptosis, etc. In addition, B7-H4 has the other biological functions, such as protection against type 1 diabetes (T1D) and islet cell transplantation. Therefore, B7-H4 has been identified as a novel marker or a therapeutic target for the treatment of tumors, inflammation, autoimmune diseases, and organ transplantation. Here, we summarized the expression profiles, physiological and pathological functions, and regulatory mechanisms of B7-H4, the signaling pathways involved, as well as B7-H4-based immunotherapy.

中文翻译：

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B7-H4，免疫疗法的有希望的目标。

共同抑制分子B7-H4是B7家族的重要成员，在肿瘤，炎症和自身免疫性疾病中异常表达。B7-H4通过抑制T细胞的增殖，细胞因子分泌和细胞周期来负调控T细胞免疫反应并促进免疫逃逸。此外，B7-H4在肿瘤发生和肿瘤发展中起着极其重要的作用，包括细胞增殖，侵袭，转移，抗凋亡等。此外，B7-H4还具有其他生物学功能，例如针对1型糖尿病（T1D）的保护。 ）和胰岛细胞移植。因此，已经将B7-H4鉴定为用于治疗肿瘤，炎症，自身免疫性疾病和器官移植的新型标志物或治疗靶标。在这里，我们总结了表达谱，生理和病理功能，