Autism spectrum disorder (ASD) is a childhood-onset neurodevelopmental disorder challenged in social reciprocity and restrictive repetitive behaviors. Here, we generated an induced pluripotent stem cell (iPSC) line SDQLCHi014-A from a patient with ASD and hyperactivity, carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene by reprogramming urine cells with non-integrating vectors. SDQLCHi014-A have shown full pluripotency, differentiation capacity and genetic stability. This iPSC line provides a valuable resource to study the molecular mechanisms underlying ASD.

中文翻译：

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诱导的多能干细胞系（SDQLCHi014-A）源自患有ASD的多动症患者，其多动症在chr3p26.1处涉及GRM7基因，携带303 kb从头删除。

自闭症谱系障碍（ASD）是在社交互惠和限制性重复行为中受到挑战的儿童期神经发育障碍。在这里，我们从患有ASD和机能亢进的患者中生成了诱导多能干细胞（iPSC）系SDQLCHi014-A，通过使用非整合型载体对尿液细胞进行重新编程，在涉及GRM7基因的chr3p26.1处携带了303 kb的从头缺失。SDQLCHi014-A已显示出充分的多能性，分化能力和遗传稳定性。该iPSC系为研究ASD的分子机制提供了宝贵的资源。