Na/K-ATPase (the sodium pump) was discovered in the 1950s as the plasma membrane enzyme that carries out the coupled active transports of Na+ and K+ across the membranes of nearly all eukaryotic cells. It was not until the 1990s when it was shown that besides pumping ions, Na/K-ATPase is also capable of stimulus-induced interactions with neighboring proteins that lead to activations of signal transduction pathways causing cell growth. This article is an attempt to review the progress of the research on these signaling functions of sodium pump during the past 2-3 decades. The covered topics include (a) the controversial digitalis-induced growth activations through the epidermal growth factor receptor and Src kinase in cardiac myocytes and several other cell types; (b) the extensive findings on digitalis-induced growth activations in cardiac myocytes and other cell types through phosphatidylinositol 3-kinases; and (c) a number of interesting but insufficiently studied signaling functions of the sodium pump.

中文翻译：

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钠泵的其他功能。

Na / K-ATPase（钠泵）是在1950年代发现的质膜酶，可在几乎所有真核细胞的膜上进行Na +和K +的耦合主动转运。直到1990年代才表明，除了泵送离子外，Na / K-ATPase还能够刺激与邻近蛋白的相互作用，从而激活导致细胞生长的信号转导途径。本文旨在回顾过去2-3年中钠泵这些信号传导功能的研究进展。涵盖的主题包括：（a）争议性的洋地黄通过心肌细胞和其他几种细胞类型中的表皮生长因子受体和Src激酶引起的生长活化；（b）关于洋地黄诱导的通过磷脂酰肌醇3-激酶在心肌细胞和其他细胞类型中的生长活化的广泛发现；（c）钠泵的许多有趣但尚未充分研究的信号传导功能。