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Anti-cancer activities of metal-based complexes by regulating the VEGF/VEGFR2 signaling pathway and apoptosis-related factors Bcl-2, Bax, and caspase-9 to inhibit angiogenesis and induce apoptosis.
Metallomics ( IF 3.4 ) Pub Date : 2019-11-04 , DOI: 10.1039/c9mt00248k
Xiu-Ying Qin 1 , Ya-Nan Wang , Han-Fu Liu , Zhao-Hui Luo , Pei-Lu Zhang , Huang Li-Fang , Mei-Rong Liu
Affiliation  

Three novel single crystals of the metal-based complexes Cu-1, Cu-2, and Co-1 were obtained and characterized. Compared with Cu-2 and Co-1, Cu-1 showed remarkable activities of anti-cervical cancer, anti-cisplatin-resistant non-small cell lung cancer and anti-angiogenesis by downregulating the expressions of important proteins in the VEGF/VEGFR2 signaling pathway to inhibit angiogenesis and cancer cell proliferation, induce apoptosis, and suppress migration and metastasis. Moreover, Cu-1 dramatically inhibited the expression of the anti-apoptotic protein Bcl-2 and up-regulated the expressions of the proapoptotic proteins caspase-9 and Bax to induce the apoptosis of tumor cells, simultaneously decreasing the density of endothelial cells to inhibit tumor angiogenesis in cisplatin-resistant tumors.

中文翻译:

金属基复合物的抗癌活性可通过调节VEGF / VEGFR2信号通路和凋亡相关因子Bcl-2,Bax和caspase-9来抑制血管生成并诱导凋亡。

获得并表征了三种基于金属的配合物Cu-1,Cu-2和Co-1的新型单晶。与Cu-2和Co-1相比,Cu-1通过下调VEGF / VEGFR2信号中重要蛋白的表达,显示出显着的抗宫颈癌,抗顺铂非小细胞肺癌和抗血管生成活性。抑制血管生成和癌细胞增殖,诱导细胞凋亡并抑制迁移和转移的途径。此外,Cu-1显着抑制抗凋亡蛋白Bcl-2的表达,并上调凋亡蛋白caspase-9和Bax的表达以诱导肿瘤细胞凋亡,同时降低内皮细胞密度以抑制肿瘤细胞凋亡。顺铂耐药肿瘤中的肿瘤血管生成。
更新日期:2019-11-04
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