We report an amination of mesylated cyclobutanol enabled by a multistep continuous flow process. The flow sequence involved an azidation followed by a Staudinger reduction which avoids the handling and isolation of a hazardous alkyl azide compound. The process is stereospecific with the azidation step proceeding to complete stereochemical inversion.

中文翻译：

---

连续流动中甲磺酸化环丁醇的立体定向胺化

我们报告了通过多步连续流动过程实现的甲磺酸化环丁醇的胺化反应。流程涉及叠氮化，然后进行Staudinger还原，从而避免了危险的叠氮化物化合物的处理和分离。该过程是立体特异的，随后进行叠氮化步骤以完成立体化学反转。