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Death by microglia.
Journal of Experimental Medicine ( IF 15.3 ) Pub Date : 2019-10-23 , DOI: 10.1084/jem.20191536
Shahrnaz Kemal 1 , Robert Vassar 2
Affiliation  

The roles of microglia and ApoE in tauopathies, such as Alzheimer's disease, remain elusive. In this issue, Shi et al. (https://doi.org/10.1084/jem.20190980) demonstrate that microglia-mediated innate immunity collaborates with ApoE to drive neurodegeneration and disease progression in a mouse model of tauopathy.

中文翻译:

小胶质细胞死亡。

小胶质细胞和 ApoE 在 tau蛋白病(如阿尔茨海默病)中的作用仍然难以捉摸。在本期中,石等人。(https://doi.org/10.1084/jem.20190980) 证明小胶质细胞介导的先天免疫与 ApoE 协同作用,在 tau 蛋白病小鼠模型中驱动神经退行性病变和疾病进展。
更新日期:2019-11-04
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