A novel, simple, sensitive method was developed for determining midodrine spectrofluorimetrically in both its raw pure form and its tablet form. This study is based on the native fluorescence of midodrine and discusses the optimum solvent used and the wavelength range. The presented method was then validated with respect to linearity, accuracy, precision, and limits of detection and quantitation. The constructed calibration curve showed a linear range of 0.1-2.0 μg/ml. The limit of detection and limit of quantitation values were 0.03 and 0.10 μg/ml respectively. Finally, content uniformity testing was applied according to the United States Pharmacopoeia by adapting the presented method.

中文翻译：

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一种简单的超灵敏荧光荧光法测定片剂形式的米多君：用于含量均匀性测试。

开发了一种新颖，简单，灵敏的方法，用于以光谱法测定米多君的原始纯净形式和片剂形式。这项研究基于米多君的天然荧光，并讨论了使用的最佳溶剂和波长范围。然后就线性，准确性，精密度以及检测和定量限验证了所提出的方法。构建的校准曲线显示0.1-2.0μg/ ml的线性范围。检测极限和定量值极限分别为0.03和0.10μg/ ml。最后，根据美国药典的规定，采用所提出的方法进行含量均一性测试。