Heteronuclear long‐range scalar coupling constants (nJCH) are a valuable tool for solving problems in organic chemistry and are especially suited for stereochemical and configurational analyses of small molecules and natural products. This tutorial will focus on the step‐by‐step implementation of several 2D 1H frequency selective HSQMBC experiments for the easy and accurate measurement of either the magnitude or both the magnitude and the sign of long‐range nJCH couplings. The performance of these experiments will be showcased with several scenarios in a range of different experimental conditions.

中文翻译：

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如何从 1 H 选择性 HSQMBC 实验中测量长程质子-碳耦合常数

异核长程标量耦合常数 (nJCH) 是解决有机化学问题的重要工具，尤其适用于小分子和天然产物的立体化学和构型分析。本教程将重点介绍几个 2D 1H 频率选择性 HSQMBC 实验的逐步实施，以便轻松准确地测量长距离 nJCH 耦合的幅度或幅度和符号。这些实验的性能将通过一系列不同实验条件下的几种场景进行展示。