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Comparative Assessment of the Sensitivity of Fish Early-Life Stage, Daphnia, and Algae Tests to the Chronic Ecotoxicity of Xenobiotics: Perspectives for Alternatives to Animal Testing.
Environmental Toxicology and Chemistry ( IF 4.1 ) Pub Date : 2019-10-09 , DOI: 10.1002/etc.4607
Elisabet Teixidó 1 , David Leuthold 1 , Noémie de Crozé 2 , Marc Léonard 2 , Stefan Scholz 1
Affiliation  

No-observed-effect concentrations (NOECs) are used in environmental hazard classification and labeling of chemicals and their environmental risk assessment. They are typically obtained using standard tests such as the fish early-life stage (FELS) toxicity test, the chronic Daphnia reproduction test, and the algae growth inhibition test. Given the demand to replace and reduce animal tests, we explored the impact of the FELS toxicity test on the determination of effect concentrations by comparing the FELS toxicity test and the Daphnia and algae acute or chronic toxicity tests. Lowest-observed-effect concentrations (LOECs) were used instead of NOECs for better comparison with median lethal or effect concentration data. A database of FELS toxicity data for 223 compounds was established. Corresponding Daphnia and algae toxicity tests were identified using established databases (US Environmental Protection Agency ECOTOX, Organisation for Economic Co-operation and Development QSAR Toolbox, eChemPortal, EnviroTox, and OpenFoodTox). Approximately 9.5% of the investigated compounds showed a 10-fold higher sensitivity with the FELS toxicity test in comparison with the lowest effect concentrations obtained with any of the other tests. Some of these compounds have been known or considered as endocrine disrupting, or are other non-narcotic chemicals, indicating that the higher sensitivity in the FELS toxicity test is related to a specific mechanism of action. Targeting these mechanisms by alternative test systems or endpoints, using fish embryos for instance, may allow reduction or replacement of the FELS toxicity test or may allow us to prioritize compounds for conduction of the FELS toxicity test. Environ Toxicol Chem 2019;39:30-41. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.

中文翻译:

鱼类早期生命阶段,水蚤和藻类检测对异源生物慢性生态毒性的敏感性的比较评估:替代动物检测的观点。

未观察到的影响浓度(NOEC)用于环境危害分类和化学品标签及其环境风险评估。它们通常使用标准测试获得,例如鱼类早期生命阶段(FELS)毒性测试,慢性水蚤繁殖测试和藻类生长抑制测试。考虑到替换和减少动物试验的需求,我们通过比较FELS毒性试验和水蚤和藻类急性或慢性毒性试验,探索了FELS毒性试验对确定效应浓度的影响。使用最低观测效应浓度(LOEC)代替NOEC,以便更好地与中位致死浓度或效应浓度数据进行比较。建立了223种化合物的FELS毒性数据数据库。使用已建立的数据库(美国环境保护署ECOTOX,经济合作与发展组织QSAR Toolbox,eChemPortal,EnviroTox和OpenFoodTox)确定了相应的水蚤和藻类毒性测试。与其他测试中最低的效果浓度相比,FELS毒性测试中约有9.5%的化合物显示出高10倍的敏感性。这些化合物中的某些已知或被认为是破坏内分泌的物质,或者是其他非麻醉性化学物质,表明FELS毒性试验中较高的敏感性与特定的作用机制有关。例如,使用鱼胚,通过其他测试系统或终点来针对这些机制,可能会减少或替代FELS毒性测试,或者可能使我们能够优先进行FELS毒性测试的化合物。Environ Toxicol Chem 2019; 39:30-41。©2019作者。Wiley Periodicals,Inc.代表SETAC出版的《环境毒理学和化学》。
更新日期:2019-12-27
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