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Aqua‐mediated rapid and benign synthesis of 1,2,6,7‐tetrahydro‐8H‐indeno[5,4‐b]furan‐8‐one‐appended novel 2‐arylidene indanones of pharmacological interest at ambient temperature
Journal of the Chinese Chemical Society ( IF 1.8 ) Pub Date : 2019-07-15 , DOI: 10.1002/jccs.201900015
Vishnu A. Adole 1 , Thansing B. Pawar 1 , Bapu S. Jagdale 1
Affiliation  

In the present investigation, a green aqua‐mediated protocol for the synthesis of novel 2‐arylidene indanone derivatives from 1,2,6,7‐tetrahydro‐8H‐indeno[5,4‐b]furan‐8‐one was unveiled. The application of water in organic reactions as a solvent is one of the incredible tools of green chemistry as reactions can be carried out under benign conditions minimizing environmental hazard and chemical waste. A library of novel 2‐arylidene indanone derivatives are synthesized in good to excellent yield by utilizing the green potential of water as a solvent. The structures of all novel 2‐arylidene indanone derivatives reported herein are confirmed using Fourier‐transform infrared spectroscopy (FTIR), 1H NMR, 13C NMR, 19F NMR, distortionless enhancement by polarization transfer (DEPT), and High Resolution Mass Spectrometry (HRMS) techniques.

中文翻译:

在环境温度下,Aqua介导的1,2,6,7-四氢-8H-茚并[5,4-b]呋喃-8-一追加的新型2-芳基茚满酮的快速良性合成

在本研究中,揭示了一种绿色的水介导的方案,用于从1,2,6,7-四氢-8H-茚并[5,4-b]呋喃-8-one合成新型2-芳基茚满酮衍生物。在有机反应中将水用作溶剂是绿色化学不可思议的工具之一,因为反应可以在良好的条件下进行,从而最大程度地减少了环境危害和化学废物。利用水的绿色潜力作为溶剂,可以很好地合成优异的新型2-芳基茚满酮衍生物库。使用傅里叶变换红外光谱(FTIR),1 H NMR,13 C NMR,19确认了本文报道的所有新型2-亚芳基茚满酮衍生物的结构。F NMR,通过极化转移(DEPT)进行的无失真增强和高分辨率质谱(HRMS)技术。
更新日期:2020-02-14
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