Intrathecal inflammation, compartmentalized in cerebrospinal fluid (CSF) and in meningeal infiltrates, has fundamental role in inflammation, demyelination, and neuronal injury in cerebral cortex in multiple sclerosis (MS). Since the exact link between intrathecal inflammation and mechanisms of cortical pathology remains unknown, we aimed to investigate a detailed proteomic CSF profiling which is able to reflect cortical damage in early MS.

中文翻译：

---

铁稳态，补体和凝血级联作为早期多发性硬化症皮层病变的CSF标志。

鞘内炎症在脑脊液（CSF）和脑膜浸润中分隔，在多发性硬化症（MS）的大脑皮层的炎症，脱髓鞘和神经元损伤中具有基本作用。由于鞘内炎症和皮层病理机制之间的确切联系仍然未知，我们旨在研究能够反映早期MS皮层损害的详细蛋白质组学CSF分析。