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Controlled synthesis of a core-shell nanohybrid for effective multimodal image-guided combined photothermal/photodynamic therapy of tumors
NPG Asia Materials ( IF 9.7 ) Pub Date : 2019-11-01 , DOI: 10.1038/s41427-019-0164-4
Qian Cheng , Zi-Hao Li , Yun-Xia Sun , Xian-Zheng Zhang

In this paper, a simple strategy is proposed to prepare a core-shell nanohybrid (PB@PCN) by the controllable coating of zirconium-porphyrin (PCN) shells on Prussian blue (PB) nanoparticles. By adjusting the thickness of the PCN shell, the PB@PCN nanohybrid with the best comprehensive performance was obtained for tumor treatment and imaging. The integrated nanosystem as a tandem catalyst is able to convert H2O2 to O2 through the PB core, and then the O2 is directly injected into the PCN framework, leading to a high quantum yield of singlet oxygen to kill tumor cells and attack heat shock proteins (HSPs). The nanohybrid was further camouflaged by a tumor cell membrane (PB@PCN@MEM) with good immune evasion and active targeting ability. Upon accumulation at the tumor site, PN@PCN@MEM showed an enhanced photodynamic therapeutic effect against hypoxic tumor cells. Furthermore, coupled with the photothermal therapy of PB, photothermal/photodynamic synergistic therapy of tumors can be realized. In addition, due to its excellent imaging performance, this core-shell nanohybrid can be employed for the multimodal image-guided therapy of tumors.



中文翻译:

核壳纳米杂合物的受控合成,用于有效的多模态图像引导的肿瘤光热/光动力联合治疗

本文提出了一种简单的策略,通过在普鲁士蓝(PB)纳米颗粒上可控地涂覆锆-卟啉(PCN)壳来制备核-壳纳米杂化物(PB @ PCN)。通过调节PCN壳的厚度,获得了具有最佳综合性能的PB @ PCN纳米杂交体,用于肿瘤治疗和成像。作为串联催化剂的集成纳米系统能够通过PB核将H 2 O 2转化为O 2,然后再将O 2转化为O 2。直接将其注射到PCN框架中,导致单线态氧的高量子产率,以杀死肿瘤细胞并攻击热休克蛋白(HSP)。具有良好免疫逃逸和主动靶向能力的肿瘤细胞膜(PB @ PCN @ MEM)进一步掩盖了纳米杂交体。在肿瘤部位积累后,PN @ PCN @ MEM对缺氧肿瘤细胞显示出增强的光动力治疗作用。此外,结合PB的光热疗法,可以实现肿瘤的光热/光动力协同疗法。另外,由于其优异的成像性能,该核-壳纳米杂交体可用于肿瘤的多峰图像引导治疗。

更新日期:2019-11-01
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