Generalized convulsive status epilepticus is associated with high mortality. We tested whether α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor plasticity plays a role in sustaining seizures, seizure generalization, and mortality observed during focal onset status epilepticus. We also determined whether modified AMPA receptors generated during status epilepticus could be targeted with a drug.

中文翻译：

---

AMPA 受体可塑性维持严重、致命的癫痫持续状态

全身性惊厥性癫痫持续状态与高死亡率相关。我们测试了 α-氨基-3-羟基-5-甲基-4-异恶唑丙酸 (AMPA) 受体可塑性是否在局灶性癫痫持续状态期间观察到的持续癫痫发作、癫痫发作泛化和死亡率中起作用。我们还确定了在癫痫持续状态期间产生的修饰的 AMPA 受体是否可以被药物靶向。