This article presents an up-to-date review of the state-of-the-art knowledge regarding the effect of sleep on the anabolic growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. This axis is involved in learning and memory and neuroprotection at the central level, and in the crosstalk between sleep and the immune system, with respect to its anti-inflammatory properties. We also aim to provide insight into the consequences of sleep loss on cognitive capacities in healthy individuals and patients with obstructive sleep apnea (OSA), regarding the mechanistic association with the GH/IGF-1 axis. Finally, this review examines the inflammatory/endocrine pathways that are affected by sleep loss, and which may consequently interact with the GH/IGF-1 axis.

The deleterious effects of sleep loss include fatigue, and can cause several adverse age-dependent health outcomes. It is therefore important to improve our understanding of the fundamental physiology underlying these effects in order to better apply non-pharmacological countermeasures (e.g., sleep strategies, exercise training, continuous positive airway pressure therapy) as well as pharmacological solutions, so as to limit the deleterious consequences of sleep loss/disorders.

本文介绍了有关睡眠对合成代谢生长激素/胰岛素样生长因子-1（GH / IGF-1）轴的影响的最新知识。就其抗炎特性而言，该轴涉及中央水平的学习，记忆和神经保护，以及睡眠与免疫系统之间的串扰。我们还旨在就与GH / IGF-1轴的机械关联，深入了解健康个体和阻塞性睡眠呼吸暂停（OSA）患者的睡眠丧失对认知能力的后果。最后，这篇综述检查了受睡眠丧失影响的炎症/内分泌途径，这些途径可能因此与GH / IGF-1轴相互作用。

睡眠不足的有害影响包括疲劳，并可能导致多种不良的年龄依赖性健康结果。因此，重要的是要增进我们对这些作用基础的基本生理学的了解，以便更好地应用非药物对策（例如睡眠策略，运动训练，持续气道正压通气疗法）以及药物解决方案，以限制睡眠丧失/疾病的有害后果。