Galectin-3 (Gal3) is a multifaceted protein which belongs to a family of lectins and binds β-galactosides. Gal3 expression is altered in many types of cancer, with increased expression generally associated with poor prognosis. Although the mechanisms remain unknown, Gal3 has been implicated in several biological processes involved in cancer progression, including suppression of T cell-mediated immune responses. Extracellular Gal3 binding to the plasma membrane of T cells alters membrane organization and the formation of an immunological synapse. Its multivalent capacity allows Gal3 to interact specifically with different membrane proteins and lipids, influencing endocytosis, trafficking and T cell receptor signalling. The ability of Gal3 to inhibit T cell responses may provide a mechanism by which Gal3 aids in cancer progression. In this review, we seek to give an overview of the mechanisms by which Gal3 alters the spatial organization of cell membranes and how these processes impact on T cell activation.

Galectin-3（Gal3）是一种多层面的蛋白质，属于凝集素家族，与β-半乳糖苷结合。在许多类型的癌症中，Gal3表达发生改变，表达增加通常与不良预后有关。尽管机理尚不清楚，但Gal3参与了与癌症发展有关的若干生物学过程，包括抑制T细胞介导的免疫反应。细胞外Gal3与T细胞质膜的结合改变了膜的组织和免疫突触的形成。它的多价能力使Gal3可以与不同的膜蛋白和脂质特异性相互作用，从而影响内吞作用，运输和T细胞受体信号传导。Gal3抑制T细胞反应的能力可以提供一种机制，通过它Gal3可以帮助癌症发展。在这篇评论中，