Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic cells and functions to induce a broad range of cellular defenses against exogenous and endogenous stresses, including oxidants, xenobiotics, and excessive nutrient/metabolite supply. Because the production and fate of stem cells are often modulated by cellular redox and metabolic homeostasis, important roles of Nrf2 have emerged in the regulation of stem cell quiescence, survival, self-renewal, proliferation, senescence, and differentiation. In a rapidly advancing field, this review summarizes Nrf2 signaling in the context of stem cell state and function and provides a rationale for Nrf2 as a therapeutic target in stem cell-based regenerative medicine.

中文翻译：

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Nrf2：干细胞状态和功能的氧化还原和代谢调节剂。

核因子类胡萝卜素2相关因子2（Nrf2）在大多数真核细胞中普遍存在，并具有诱导多种细胞防御外源和内源性胁迫的功能，包括氧化剂，异源生物和营养/代谢物供应过多。由于干细胞的产生和命运通常受到细胞氧化还原和代谢稳态的调节，因此Nrf2在调节干细胞的静止，存活，自我更新，增殖，衰老和分化中发挥了重要作用。在快速发展的领域中，这项综述总结了Nrf2在干细胞状态和功能方面的信号，并为Nrf2作为基于干细胞的再生医学中的治疗靶标提供了理论依据。