当前位置: X-MOL 学术Semin. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Epigenetic and transcriptional mechanisms for the regulation of IL-10.
Seminars in Immunology ( IF 7.8 ) Pub Date : 2019-10-30 , DOI: 10.1016/j.smim.2019.101324
Huiyuan Zhang 1 , Vijay Kuchroo 2
Affiliation  

IL-10 is a critical immunoregulatory cytokine expressed in virtually all immune cell types. Maintaining a delicate balance between effective immune response and tolerance requires meticulous and dynamic control of IL-10 expression both epigenetically and transcriptionally. In this Review, we describe the epigenetic mechanisms controlling IL-10 expression, including chromatin remodeling, 3D chromatin loops, histone modification and DNA methylation. We discuss the role of transcription factors in directing chromatin modifications, with a special highlight on the emerging concept of pioneer transcription factors in setting up the chromatin landscape in T helper cells for IL-10 induction. Besides summarizing the recent progress on transcriptional regulation in specialized IL-10 producers such as type 1 regulatory T cells, regulatory B cells and regulatory innate lymphoid cells, we also discuss common transcriptional mechanisms for IL-10 regulation that are shared with other IL-10 producing cells.



中文翻译:

IL-10的表观遗传和转录机制。

IL-10是实际上在所有免疫细胞类型中表达的关键免疫调节细胞因子。要在有效的免疫反应和耐受性之间保持微妙的平衡,就需要在表观遗传和转录上对IL-10表达进行细致而动态的控制。在这篇综述中,我们描述了控制IL-10表达的表观遗传机制,包括染色质重塑,3D染色质环,组蛋白修饰和DNA甲基化。我们讨论了转录因子在指导染色质修饰中的作用,并特别介绍了先驱转录因子在建立T辅助细胞中的IL-10诱导染色质景观方面的新兴概念。除了总结专门IL-10生产商(例如1型调节性T细胞)在转录调控方面的最新进展外,

更新日期:2019-10-30
down
wechat
bug