Immunosenescence is defined as the progressive deterioration of the immune system with aging. Immunosenescence stifles the generation of protective B and T cell-mediated adaptive immunity in response to various pathogens, resulting in increased disease susceptibility and severity in the elderly population. In particular, immunosenescence has major impacts on the phenotype, function, and receptor repertoire of B and T cells in the elderly, hindering protective responses induced by seasonal influenza virus vaccination. In order to overcome the detrimental impacts of immunosenescence on protective immunity to influenza viruses, we review our current understanding of the effects of aging on adaptive immune responses to influenza and discuss current and future avenues of vaccine research for eliciting more potent anti-influenza immunity in the elderly.

中文翻译：

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衰老和流感疫苗诱导的免疫力。

免疫衰老定义为免疫系统随着年龄的增长而逐渐恶化。免疫衰老抑制了响应各种病原体的保护性B和T细胞介导的适应性免疫的产生，从而导致老年人的疾病易感性和严重性增加。尤其是，免疫衰老对老年人的B细胞和T细胞的表型，功能和受体组成具有重大影响，从而阻碍了季节性流感病毒疫苗接种诱导的保护性反应。为了克服免疫衰老对流感病毒保护性免疫的有害影响，我们回顾了我们目前对衰老对流感适应性免疫反应的影响的理解，并讨论了疫苗研究的当前和未来途径，以在流感疫苗中激发更强的抗流感免疫力。老人。