Suicide is a major challenge in public health and is strongly associated with major depressive disorder (MDD). Despite recent neuroimaging developments, the neural correlates of suicide behavior in patients with MDD remain unclear. Independent component analysis (ICA) for neuroimaging data allows the identification of functional brain networks without prior regions of interest and may help to identify neurobiological markers of specific disorders. Using ICA, we investigated the differences in resting-state brain networks in patients with MDD who had or did not have a history of suicide attempts and in healthy controls (HCs). Suicidal depressed (SD) patients, non-suicidal depressed (NSD) patients, and HCs significantly differed from each other in the pattern of connectivity of multiple functional networks, network synchronization, and functional network connectivity (FNC). The patient groups had a decreased network synchronization in the insular, cerebellum, basal ganglia, thalamus, operculum, frontoparietal cortices, and sensory cortices relative to the HCs. The decreased FNC between these networks (insular-default mode network and insular-cerebellum) was found in the SD group compared to the NSD and HC groups. These differences were not related to illness duration and medication status differences between SD and NSD. Furthermore, the degree of FNC in these networks was associated with the suicide ideation and stress level. Our results demonstrated that widespread but discrete network changes in brain networks and their interconnectivity was associated with suicide attempts in patients with MDD. Our results suggest that the neural basis underlying the psychopathology of attempted suicide in patients with MDD involves multiple brain networks and their interaction.

中文翻译：

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患有自杀未遂史的抑郁症患者的功能性大脑网络发生变化。

自杀是公共卫生领域的一项重大挑战，与重度抑郁症（MDD）密切相关。尽管最近有神经影像学发展，但MDD患者自杀行为的神经相关性仍不清楚。用于神经影像数据的独立成分分析（ICA）可以识别功能性脑网络，而无需事先关注区域，并且可以帮助识别特定疾病的神经生物学标记。使用ICA，我们调查了有或没有自杀未遂史的MDD患者和健康对照者（HCs）在静止状态脑网络中的差异。自杀性抑郁（SD）患者，非自杀性抑郁（NSD）患者和HC在多功能网络的连通性模式，网络同步，和功能网络连接（FNC）。相对于HC，患者组在岛，小脑，基底神经节，丘脑、,、额顶皮质和感觉皮质的网络同步性降低。与NSD和HC组相比，在SD组中发现了这些网络之间的FNC减少（insular-default模式网络和insular小脑）。这些差异与SD和NSD之间的病程和药物状态差异无关。此外，这些网络中FNC的程度与自杀观念和压力水平有关。我们的结果表明，脑部网络中广泛而离散的网络变化及其相互联系与MDD患者的自杀未遂有关。