The possible mechanism(s) by which ribosomes make peptide bonds during protein synthesis have been explored for decades. Yet, there is no agreement on how the catalytic site, the peptidyl transferase center (PTC), promotes this reaction. Here, we discuss the results of recent investigations of translation with D amino acids that provide fresh insights into that longstanding question.

中文翻译：

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D氨基酸突出了核糖体的催化能力。

数十年来，人们一直在探索核糖体在蛋白质合成过程中形成肽键的可能机制。但是，关于催化位点，肽基转移酶中心（PTC）如何促进该反应尚无共识。在这里，我们讨论了最近D氨基酸翻译研究的结果，这些研究为这一长期存在的问题提供了新的见解。