Mammalian sirtuins have emerged in recent years as critical modulators of multiple biological processes, regulating cellular metabolism, DNA repair, gene expression, and mitochondrial biology. As such, they evolved to play key roles in organismal homeostasis, and defects in these proteins have been linked to a plethora of diseases, including cancer, neurodegeneration, and aging. In this review, we describe the multiple roles of SIRT6, a chromatin deacylase with unique and important functions in maintaining cellular homeostasis. We attempt to provide a framework for such different functions, for the ability of SIRT6 to interconnect chromatin dynamics with metabolism and DNA repair, and the open questions the field will face in the future, particularly in the context of putative therapeutic opportunities.

中文翻译：

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SIRT6，一种具有多任务处理能力的哺乳动物脱酰酶。

近年来，哺乳动物去乙酰化酶已成为多种生物过程的关键调节剂，调节细胞代谢、DNA 修复、基因表达和线粒体生物学。因此，它们进化为在机体稳态中发挥关键作用，而这些蛋白质的缺陷与多种疾病有关，包括癌症、神经退行性变和衰老。在这篇综述中，我们描述了 SIRT6 的多重作用，SIRT6 是一种染色质脱酰酶，在维持细胞稳态方面具有独特而重要的功能。我们试图为这些不同的功能、SIRT6 将染色质动力学与代谢和 DNA 修复互连的能力，以及该领域未来将面临的开放性问题（特别是在假定的治疗机会的背景下）提供一个框架。