Laser biological effects are a hot topic in laser medicine. In this study, to explore the quantitative biological effect of laser-induced wound healing and to provide guidance for expanding the clinical application of laser therapy, the injury effects and repair characteristics of skin tissue are studied through infrared laser irradiation of the skin of miniature pigs. Live pig skin was irradiated at multiple spots one time by using a grid-array method with a 1064 nm laser at different power outputs. The skin injury reaction was observed immediately after laser irradiation from low to high doses. The incidence of skin injury was calculated quantitatively. The healing and pathological changes after laser-induced skin injury were observed dynamically within 6 h and for 28 d after laser irradiation. With the increase of irradiation dose, laser-induced skin injuries ranging from mild to severe appeared in turn. The damage threshold of laser irradiation ED 50 is 47.4 J cm

中文翻译：

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1064 nm激光对激光诱发的皮肤损伤恢复过程的定量和定性评估：体内实验研究

激光生物学效应是激光医学中的热门话题。为探讨激光诱导伤口愈合的定量生物学效应，为扩大激光治疗的临床应用提供指导，通过红外激光照射小型猪的皮肤，研究了其对皮肤组织的损伤效应和修复特性。 。使用栅格阵列方法用1064 nm激光以不同的功率输出一次在多处照射活猪皮肤。从低剂量到高剂量激光照射后，立即观察到皮肤损伤反应。定量计算皮肤损伤的发生率。激光照射后6 h内和28 d内动态观察激光诱导的皮肤损伤后的愈合和病理变化。随着辐照剂量的增加，激光引起的皮肤伤害从轻度到重度依次出现。ED 50激光照射的损伤阈值为47.4 J cm