Metastasis is a pivotal event that changes the course of cancers from benign and treatable to malignant and difficult to treat, resulting in the demise of patients. Understanding the genetic control of metastasis is thus crucial to develop efficient and sustainable targeted therapies. Here we discuss the alterations in epigenetic mechanisms, transcription, chromosomal instability, chromosome imprinting, non‐coding RNAs, coding RNAs, mutant RNAs, enhancers, G‐quadruplexes, and copy number variation to dissect the genetic control of metastasis. We conclude that the genetic control of metastasis is predominantly executed through epithelial to mesenchymal transition and evasion of cell death. We discuss how genetic regulatory mechanisms can be harnessed for therapeutic purposes to achieve sustainable control over cancer metastasis.

中文翻译：

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转移的遗传脚本

转移是一个关键事件，它将癌症的病程从良性和可治疗转变为恶性和难以治疗，从而导致患者死亡。因此，了解转移的遗传控制对于开发有效和可持续的靶向治疗至关重要。在这里，我们讨论表观遗传机制、转录、染色体不稳定性、染色体印记、非编码 RNA、编码 RNA、突变 RNA、增强子、G-四链体和拷贝数变异的改变，以剖析转移的遗传控制。我们得出结论，转移的遗传控制主要通过上皮间充质转化和细胞死亡逃避来执行。我们讨论了如何将基因调控机制用于治疗目的，以实现对癌症转移的可持续控制。