iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine tumor necrosis factor–α (TNF-α) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling, Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.

中文翻译：

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iRhom2和TNF：是伙伴还是敌人？

iRhom2是ADAM17的必需辅助因子，ADAM17是一种金属蛋白酶，可从细胞表面释放促炎性细胞因子肿瘤坏死因子–α（TNF-α）和TNF受体（TNFRs）。在本期《科学信号》中，Sundaram等人。证明iRhom2促进肝星状细胞中ADAM17介导的TNFR脱落的保护作用，从而减少TNFR信号转导和肝纤维化对损伤的反应。