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Circulating levels of gastrointestinal hormones in response to the most common types of bariatric surgery and predictive value for weight loss over one year: Evidence from two independent trials.
Metabolism ( IF 9.8 ) Pub Date : 2019-10-28 , DOI: 10.1016/j.metabol.2019.153997
Nikolaos Perakakis 1 , Alexander Kokkinos 2 , Natia Peradze 1 , Nikolaos Tentolouris 2 , Wael Ghaly 3 , Eleni Pilitsi 1 , Jagriti Upadhyay 1 , Andreas Alexandrou 4 , Christos S Mantzoros 5
Affiliation  

AIMS Bariatric surgery leads to profound and sustainable weight loss. Gastrointestinal hormones are involved in energy and glucose homeostasis, thus postoperative changes of their circulating levels may be mediating future weight loss. To investigate how the circulating concentrations of gastrointestinal hormones change in response to the most common types of bariatric operation and whether these changes can predict future weight loss. MATERIALS AND METHODS We measured circulating GLP-1, GLP-2, oxyntomodulin, glicentin, glucagon, major proglucagon fragment (MPGF), ghrelin, GIP, PYY after overnight fasting and/or after a mixed meal test (MMT) in: a) 14 subjects that have undergone either an adjustable gastric banding [AGB] (n = 9) or a Roux-en-Y bypass (RYGB) (n = 5) (Pilot study 1), b) 28 subjects that have undergone either a vertical sleeve gastrectomy (n = 17) or a RYGB (n = 11) before and three, six and twelve months after surgery. RESULTS In addition to the expected associations with GLP-1, the most robust increases were observed in postprandial levels of oxyntomodulin and glicentin three months after VSG or RYGB (but not after AGB) and are associated with degree of weight loss. Oxyntomodulin and glicentin levels at the third and sixth month postoperative visit are positively associated with feeling of satiety which may be underlying the observed associations with future weight loss. CONCLUSION Beyond GLP-1, early postprandial changes in circulating oxyntomodulin and glicentin are predictors of weight loss after bariatric surgery, possibly through regulation of satiety. Further studies should focus on underlying mechanisms, and their potential as attractive therapeutic tools against obesity and related comorbidities.

中文翻译:

减肥手术最常见类型对胃肠激素的循环水平和一年以上减肥的预测价值:来自两项独立试验的证据。

AIMS减肥手术可带来深刻且可持续的减肥效果。胃肠激素与能量和葡萄糖稳态有关,因此术后循环水平的改变可能会介导未来的体重减轻。调查胃肠激素的循环浓度如何响应最常见的减肥手术而改变,以及这些改变是否可以预测未来的体重减轻。材料和方法我们在过夜禁食后和/或混合餐试验(MMT)后测量了循环中的GLP-1,GLP-2,胃泌素调节素,glicentin,胰高血糖素,主要胰高血糖素前体片段(MPGF),生长素释放肽,GIP,PYY,其中: 14位受试者接受了可调整的胃束带[AGB](n = 9)或Roux-en-Y旁路(RYGB)(n = 5)(先导研究1),b)28名在手术前和手术后三个月,六个月和十二个月接受了垂直袖胃切除术(n = 17)或RYGB(n = 11)的受试者。结果除了预期与GLP-1的相关性外,在VSG或RYGB三个月后(而非AGB后),在餐后胃泌素调节素和glicentin的水平上观察到最强劲的增加,并且与体重减轻程度相关。术后第三和第六个月的胃泌素调节素和glicentin水平与饱腹感成正相关,这可能是观察到的与未来体重减轻之间的关联。结论除了GLP-1,餐后循环中的胃泌酸调节素和glicentin的早期变化是减肥手术后体重减轻的预测指标,可能是通过调节饱腹感来实现的。
更新日期:2019-10-28
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