Room-Temperature-Formed PEDOT:PSS Hydrogels Enable Injectable, Soft, and Healable Organic Bioelectronics.,Advanced Materials

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Room-Temperature-Formed PEDOT:PSS Hydrogels Enable Injectable, Soft, and Healable Organic Bioelectronics.
Advanced Materials ( IF 29.4 ) Pub Date : 2019-10-28 , DOI: 10.1002/adma.201904752
Shiming Zhang _{1,

2,

3,

4} , Yihang Chen _{2,

3,

5} , Hao Liu _{1,

2,

3,

6,

7} , Zitong Wang _{1,

2,

3} , Haonan Ling _{2,

3,

8} , Changsheng Wang ₉ , Jiahua Ni _{1,

2,

3} , Betül Çelebi-Saltik _{1,

2,

3} , Xiaochen Wang _{1,

2,

3} , Xiang Meng ₁₀ , Han-Jun Kim _{1,

2,

3} , Avijit Baidya _{1,

2,

3} , Samad Ahadian _{1,

2,

3} , Nureddin Ashammakhi _{2,

3,

11} , Mehmet R Dokmeci _{2,

3,

11} , Jadranka Travas-Sejdic _{12,

13} , Ali Khademhosseini _{1,

2,

3,

11,

14}

Affiliation

Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, 90095, USA.
California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
Department of Chemistry, University of Montreal, Montreal, QC, H3T 2B1, Canada.
Department of Materials Science and Engineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Department of Mechanical and Aerospace Engineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
Department of Stem Cell Sciences, Graduate School of Health Sciences, Hacettepe University, Sihhiye, 06100, Ankara, Turkey.
Department of Engineering Physics, Polytechnique Montreal, Montreal, QC, H3C 3A7, Canada.
Department of Radiology, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
Polymer Electronic Research Centre, School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, 1023, New Zealand.
MacDiarmid Institute for Advanced Materials and Nanotechnology, Kelburn Parade, Wellington, 6140, New Zealand.
Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

There is an increasing need to develop conducting hydrogels for bioelectronic applications. In particular, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hydrogels have become a research hotspot due to their excellent biocompatibility and stability. However, injectable PEDOT:PSS hydrogels have been rarely reported. Such syringe-injectable hydrogels are highly desirable for minimally invasive biomedical therapeutics. Here, an approach is demonstrated to develop injectable PEDOT:PSS hydrogels by taking advantage of the room-temperature gelation property of PEDOT:PSS. These PEDOT:PSS hydrogels form spontaneously after syringe injection of the PEDOT:PSS suspension into the desired location, without the need of any additional treatments. A facile strategy is also presented for large-scale production of injectable PEDOT:PSS hydrogel fibers at room temperature. Finally, it is demonstrated that these room-temperature-formed PEDOT:PSS hydrogels (RT-PEDOT:PSS hydrogel) and hydrogel fibers can be used for the development of soft and self-healable hydrogel bioelectronic devices.

中文翻译：

室温形成的 PEDOT:PSS 水凝胶可实现可注射、柔软且可愈合的有机生物电子学。

开发用于生物电子应用的导电水凝胶的需求日益增加。特别是聚(3,4-乙撑二氧噻吩):聚(苯乙烯磺酸)(PEDOT:PSS)水凝胶因其优异的生物相容性和稳定性而成为研究热点。然而，可注射的PEDOT:PSS水凝胶却鲜有报道。这种注射器可注射水凝胶对于微创生物医学治疗来说是非常理想的。在这里，展示了一种利用 PEDOT:PSS 的室温凝胶特性开发可注射 PEDOT:PSS 水凝胶的方法。将 PEDOT:PSS 悬浮液注射到所需位置后，这些 PEDOT:PSS 水凝胶会自发形成，无需任何额外的处理。还提出了一种在室温下大规模生产可注射 PEDOT:PSS 水凝胶纤维的简便策略。最后，证明这些室温形成的PEDOT:PSS水凝胶（RT-PEDOT:PSS水凝胶）和水凝胶纤维可用于开发柔软且可自修复的水凝胶生物电子器件。

更新日期：2020-01-07

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