2D black phosphorus (BP) nanosheets and BP quantum dots (BPQD), as two main material styles of BP, are widely used in the biomedical filed. However, few stimuli‐responsive BP nanocarriers are reported to meet the need of nanomedicine. Herein, near‐infrared region/reactive oxygen species (NIR/ROS) sensitive BPQD vesicles (BPNVs) are prepared by self‐assembly of amphiphilic BPQDs grafted with polyethylene glycol and ROS sensitive poly(propylene sulfide) (PPS). BPNVs exhibit enhanced photo‐absorption in the NIR region, and have high loading efficiency of immunoadjuvant CpG oligodeoxynucleotides (CpG ODNs) in the cavity of the BPNVs. Upon NIR laser irradiation, high levels of ROS are generated from BPNVs to trigger the change of hydrophobic PPS to hydrophilic polymers, leading to disassembly of the vesicles to BPQDs. In this manner, the BPNVs show synergistic photodynamic therapy combined with immunotherapy, due to simultaneous release of small BPQDs with deep tumor penetration and CpG with enhanced immunotherapy. The BPNVs‐CpG achieves potent photodynamic immunotherapy in vivo, in addition to block distant tumor growth and metastasis.

中文翻译：

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NIR / ROS反应性黑色磷QD囊泡作为特定癌症光动力免疫疗法的免疫佐剂载体

二维黑磷（BP）纳米片和BP量子点（BPQD）作为BP的两种主要材料样式，已广泛应用于生物医学领域。但是，据报道很少有刺激响应性的BP纳米载体可以满足纳米医学的需求。在这里，近红外区/活性氧（NIR / ROS）敏感的BPQD囊泡（BPNVs）是通过自组装了聚乙二醇和ROS敏感的聚硫化丙烯（PPS）的两亲BPQD组装而成的。BPNV在NIR区域显示出增强的光吸收，并且在BPNV的腔中具有较高的免疫佐剂CpG寡脱氧核苷酸（CpG ODN）加载效率。在NIR激光照射下，BPNV产生大量ROS，从而引发疏水性PPS转变为亲水性聚合物，从而导致囊泡分解为BPQD。以这种方式，BPNV显示出协同光动力疗法与免疫疗法的结合，这是由于同时释放了具有深肿瘤穿透力的小BPQD和具有增强免疫疗法的CpG。BPNVs-CpG除了可以阻止远处的肿瘤生长和转移外，还可以在体内实现有效的光动力免疫治疗。