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Unravelling interspecies interactions across heterogeneities in complex biofilm communities.
Environmental Microbiology ( IF 5.1 ) Pub Date : 2019-11-10 , DOI: 10.1111/1462-2920.14834
Henriette L Røder 1 , Nanna M C Olsen 1 , Marvin Whiteley 2, 3, 4 , Mette Burmølle 1
Affiliation  

The importance of microbial biofilms has been well-recognized for several decades, and focus is now shifting towards investigating multispecies biofilm communities rather than mono- or dual-species biofilms. Therefore, the demand for techniques that provide a sufficient amount of information at adequate resolution is increasing. One major challenge for multispecies studies is that diversity and spatial organization often lead to a high degree of spatial and chemical heterogeneity. Many current approaches do not account for such heterogeneity and therefore only provide average information (-omics techniques in particular), which could obscure important information about the community. Here, we bring attention to the issues of heterogeneity when analysing synthetic multi-species biofilms, in vitro, and the importance of multi-scale approaches. We provide an overview of current and newer approaches that can be applied to biofilm communities, in order to elucidate interactions at the appropriate scale.

中文翻译:

揭示复杂生物膜群落中异质性之间的种间相互作用。

几十年来,人们已经充分认识到微生物生物膜的重要性,并且现在的重点正在转向研究多物种生物膜群落,而不是单物种或双物种生物膜。因此,对于以足够的分辨率提供足够的信息量的技术的需求正在增加。多物种研究的一个主要挑战是多样性和空间组织常常导致高度的空间和化学异质性。当前许多方法并未解决这种异质性问题,因此仅提供平均信息(尤其是组学技术),这可能会使有关社区的重要信息模糊不清。在这里,当我们在体外分析合成的多种生物膜时,我们将注意力集中在异质性问题上,以及多尺度方法的重要性。
更新日期:2020-01-02
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