As the field of synthetic chemistry seeks to tackle new frontiers, total synthesis is primed to address significant medical challenges such as the rise of antibiotic resistance and cancer. One emerging frontier focuses on increasingly concerted efforts to utilize modular total synthesis as a strategy to generate analogs of natural product targets for biological studies, with the ultimate goal of new therapeutic development. This new frontier is enabled by a confluence of human ingenuity in synthetic design, newly developed reactions that facilitate advances in total synthesis strategies, and emerging technologies. In this review, we highlight the evolving trend of modular total synthesis, including new reactions and automated technologies. This trend should lead to an increasingly important source of new medicines to improve human health.

随着合成化学领域寻求新的领域，全合成已准备就绪，可以应对重大的医学挑战，例如抗生素耐药性和癌症的上升。一个新兴的前沿集中于越来越多的协同努力，以利用模块化的全合成作为一种策略，以生成用于生物学研究的天然产物靶标的类似物，最终目标是开发新的治疗方法。人类合成设计的独创性，促进总合成策略发展的新开发反应以及新兴技术为这一新领域提供了支持。在这篇综述中，我们重点介绍了模块化总合成的发展趋势，包括新的反应和自动化技术。这种趋势将导致越来越重要的新药来源改善人类健康。