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Metabolic Messengers: ceramides.
Nature Metabolism ( IF 20.8 ) Pub Date : 2019-10-24 , DOI: 10.1038/s42255-019-0134-8
Scott A Summers 1 , Bhagirath Chaurasia 1 , William L Holland 1
Affiliation  

Ceramides are products of metabolism that accumulate in individuals with obesity or dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when prolonged, elicit the tissue dysfunction that underlies diabetes and heart disease. Here, we review the history of research on these enigmatic molecules, exploring their discovery and mechanisms of action, the evolutionary pressures that have given them their unique attributes and the potential of ceramide-reduction therapies as treatments for cardiometabolic disease.



中文翻译:

代谢信使:神经酰胺。

神经酰胺是代谢产物,在肥胖或血脂异常的个体中积累,并改变细胞过程以响应燃料过剩。当他们的行为长期存在时,会引发导致糖尿病和心脏病的组织功能障碍。在这里,我们回顾了这些神秘分子的研究历史,探索它们的发现和作用机制,赋予它们独特属性的进化压力以及神经酰胺减少疗法作为心脏代谢疾病治疗的潜力。

更新日期:2019-10-25
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