Poly(3,4‐ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) is widely used as a coating on microelectrode arrays in order to reduce impedance for both in vitro and in vivo electrophysiology. In many applications, electrode performance of months to years is desired; yet, there are few studies to date that examine the long‐term stability of conducting polymers and their devices. Here, the stability of PEDOT:PSS microelectrodes is examined over a period of four months in cell culture media enriched with fetal bovine serum. The electrochemical impedance remains constant for most electrodes throughout the study, and only small changes in the structure of functional electrodes are observed. The results demonstrate that PEDOT:PSS electrodes show adequate stability for a variety of in vitro electrophysiology applications in toxicology, drug development, tissue engineering, and fundamental studies of electrically active cells and tissues.

中文翻译：

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PEDOT：PSS涂层金电极在细胞培养条件下的稳定性

掺杂有聚苯乙烯磺酸盐（PEDOT：PSS）的聚（3,4-亚乙基二氧噻吩）被广泛用作微电极阵列上的涂层，以降低体外和体内电生理学的阻抗。在许多应用中，需要数月至数年的电极性能。但是，迄今为止，很少有研究检查导电聚合物及其器件的长期稳定性。在这里，在富含胎牛血清的细胞培养基中，在四个月的时间内检查了PEDOT：PSS微电极的稳定性。在整个研究过程中，大多数电极的电化学阻抗均保持恒定，并且仅观察到功能性电极结构的微小变化。结果表明，PEDOT：PSS电极对于毒理学中的各种体外电生理学应用具有足够的稳定性，