In the present issue of Acta Physiologica the team of researchers lead by Robert Zorec and Milos Pekny [1] examined the role of nesting (the intermediate filament associated with proliferation and stem cell capacity) in the regulation of vesicular trafficking in reactive astrocytes in vitro. Reactive astrogliosis is a complex of biochemical, morphological and functional metamorphoses of astrocytes in response to pathological insults to the brain and to the spinal cord. Instigation of astrogliosis by various pathology‐related factors (generalised as damage‐associated and pathogen‐associated molecular patterns, DAMPs and PAMPs) produces multiple reactive phenotypes specific for the disease and context [2,3]. Conceptually, astrogliosis is a defensive response of astroglia; in certain conditions (for example in response to chronic or severe stress) it may turn maladaptive and generate neurotoxic astrocytes.

中文翻译：

---

巢蛋白调节增殖反应性星形胶质细胞中的囊泡动力学。

在本期《生理生理学》（Acta Physiologica）中，由罗伯特·佐雷克（Robert Zorec）和米洛斯·皮克尼（Milos Pekny）领导的研究小组[1]研究了嵌套（与增殖和干细胞能力有关的中间丝）在体外调节反应性星形胶质细胞中的囊泡运输中的作用。。反应性星形胶质细胞增生是星形胶质细胞的生化，形态和功能变质的复合体，对大脑和脊髓的病理损伤有反应。通过各种病理相关因素（一般称为损伤相关和病原体相关的分子模式，DAMP和PAMP）诱使星形胶质细胞增生产生针对该疾病和环境的多种反应性表型[2,3]。从概念上讲，星形胶质细胞沉着症是对星形胶质细胞的防御反应。在某些情况下（例如对慢性或重度压力的反应），它可能会变得适应不良，并产生神经毒性星形胶质细胞。