BACKGROUND Speckle-tracking strain analysis provides additive data to the assessment of pediatric and congenital heart disease; however, the variety of strain analysis software platforms by different vendors and the lack of data on intervendor strain agreement in children have limited its utility. The purpose of this study is to evaluate the intervendor agreement of strain on two commonly used analysis platforms in pediatrics by layer of myocardium and data compression. METHODS This prospective study analyzed two-dimensional speckle-tracking strain on two software platforms in 53 children with normal cardiac segmental anatomy and varying function. Three standard apical views and one parasternal short-axis view were exported at their acquired frame rates to workstations with GE EchoPAC and TomTec software and then also to TomTec at compressed frame rates. Both software platforms had been updated with European Association of Cardiovascular Imaging/American Society of Echocardiography Task Force recommendations for left ventricular (LV) global strain. Intravendor and intervendor agreement between layer-specific comparisons were assessed using Bland-Altman analysis (limits of agreement and bias) and intraclass correlation coefficients. RESULTS This study included subjects with normal LV function (n = 38) and cardiomyopathy (n = 15) with an age range of 1 month to 18 years. Intertechnique agreement by default vendor myocardial layer (GE mid-TomTec endocardial layer) was robust for both global longitudinal (GLS) and circumferential strain (GCS; higher for GLS than GCS). Intravendor (inter- and interreader) agreement was slightly higher than intervendor. Only small differences in intraclass correlation coefficients were present between various myocardial layers and acquired versus compressed TomTec data with narrow limits of agreement and small bias except in certain subgroup comparisons. CONCLUSIONS Comparison of LV GLS and GCS between two commonly used software platforms after European Association of Cardiovascular Imaging/American Society of Echocardiography Industry Task Force recommendations demonstrated good to excellent agreement in pediatrics, regardless of the layer of analysis or the image format, although some degree of variability remains between vendor platforms. Overall, GLS agreement was more robust than GCS, and this difference is exaggerated in specific subanalyses. These data suggest that comparisons of strain values obtained on these two vendors will be reasonable, but caution should be used when the indication is the detection of small differences between serial echocardiograms.

中文翻译：

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儿童的左心室整体收缩应变的可重复性和供应商协议，使用特定层分析。

背景技术斑点追踪应变分析为儿童和先天性心脏病的评估提供了补充数据。但是，不同供应商提供的应变分析软件平台种类繁多，以及儿童中供应商之间的应变协议缺乏数据，限制了其实用性。这项研究的目的是通过心肌层和数据压缩来评估两种常用的儿科分析平台上的应变之间的供应商一致性。方法这项前瞻性研究分析了53例具有正常心脏节段解剖和功能变异的儿童在两个软件平台上的二维斑点追踪应变。将三个标准的顶视图和一个胸骨旁短轴视图以其获取的帧速率导出到具有GE EchoPAC和TomTec软件的工作站，然后还以压缩帧速率导出到TomTec。两种软件平台均已更新，并附有欧洲心血管影像协会/美国超声心动图学会特别工作组对左心室（LV）整体应变的建议。使用Bland-Altman分析（一致和偏倚的限制）和类内相关系数评估特定于层之间的比较之间的内部和内部供应商一致性。结果本研究纳入了年龄正常在1个月至18岁之间的左室功能正常（n = 38）和心肌病（n = 15）的受试者。默认的供应商心肌层（GE中间TomTec心内膜层）之间的技术间协议对于全局纵向（GLS）和周向应变（GCS；对于GLS高于GCS）均很有效。供应商之间（中间人和阅读者之间）的协议略高于中间人。除某些亚组比较外，在不同的心肌层之间以及获得的和经过压缩的TomTec数据之间，在组内相关系数上仅存在很小的差异，且一致的范围狭窄且偏差较小。结论根据欧洲心血管影像协会/美国超声心动图行业工作组的建议，比较两种常用软件平台之间的LV GLS和GCS，无论在分析的层次或图像格式如何，在小儿科均显示出良好的一致性。尽管供应商平台之间仍然存在一定程度的可变性。总体而言，GLS协议比GCS更加健壮，并且在特定的子分析中夸大了这种差异。这些数据表明，比较在这两个供应商处获得的应变值是合理的，但是当指示是检测到连续超声心动图之间的微小差异时，应谨慎行事。