当前位置: X-MOL 学术Nutr. Diabetes › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The flavonoid-rich Quzhou Fructus Aurantii extract modulates gut microbiota and prevents obesity in high-fat diet-fed mice.
Nutrition & Diabetes ( IF 6.1 ) Pub Date : 2019-10-23 , DOI: 10.1038/s41387-019-0097-6
Yong-Feng Bai 1 , Si-Wei Wang 2, 3 , Xiao-Xiao Wang 4 , Yuan-Yuan Weng 1 , Xue-Yu Fan 1 , Hao Sheng 5 , Xin-Tian Zhu 6 , Li-Jun Lou 3 , Feng Zhang 1, 2, 5
Affiliation  

BACKGROUND Flavonoids are reported to modulate the composition of gut microbiota, which play an important role in preventing obesity and associated metabolic diseases. In this study, we investigated the effect of Total Flavonoids of Quzhou Fructus Aurantii Extract (TFQ) on gut microbial community in mice fed with a high-fat diet (HFD). METHODS C57BL/6J mice were fed with either a chow diet or HFD with or without oral gavage of TFQ (300 mg/kg/day) for 12 weeks. RESULTS Our data indicate TFQ significantly reduced obesity, inflammatio,n and liver steatosis. TFQ elevates the expression of tight junction proteins and reduces metabolic endotoxemia. In addition, TFQ treatment reverses HFD-induced gut dysbiosis, as indicated by the reduction of Firmicutes to Bacteroidetes ratio, the increase of genera Akkermansia and Alistipes, and the decrease of genera Dubosiella, Faecalibaculum, and Lactobacillus. CONCLUSION These findings support a prebiotic role of TFQ as a dietary supplement for the intervention of gut dysbiosis and obesity-related metabolic disorders.

中文翻译:

富含类黄酮的Qu州F果提取物可调节高脂饮食喂养小鼠的肠道菌群并防止肥胖。

背景技术据报道,类黄酮调节肠道菌群的组成,其在预防肥胖症和相关的代谢性疾病中起重要作用。在这项研究中,我们调查了Qu州五味子提取物(TFQ)中总黄酮对高脂饮食(HFD)喂养的小鼠肠道微生物群落的影响。方法对C57BL / 6J小鼠饲以低脂饮食或HFD,口服或不口服TFQ(300 mg / kg /天),持续12周。结果我们的数据表明TFQ显着降低了肥胖,发炎,肝脂肪变性。TFQ增强紧密连接蛋白的表达并减少代谢性内毒素血症。此外,TFQ治疗可逆转HFD诱导的肠道营养不良,如Firmicutes与Bacteroidetes比率的降低,Akkermansia和Alistipes属的增加,和杜氏杆菌属,Faecalibaculum和乳杆菌属的减少。结论这些发现支持TFQ的益生元作用,作为膳食补充剂,可治疗肠道营养不良和肥胖相关的代谢性疾病。
更新日期:2019-10-23
down
wechat
bug