Adenosine-to-inosine (A-to-I) editing of RNA leads to deamination of adenosine to inosine. Inosine is interpreted as guanosine by the cellular machinery, thus altering the coding, folding, splicing, or transport of transcripts. A-to-I editing is tightly regulated. Altered editing has severe consequences for human health and can cause interferonopathies, neurological disorders, and cardiovascular disease, as well as impacting on cancer progression. ADAR1-mediated RNA editing plays an important role in antiviral immunity and is essential for distinguishing between endogenous and viral RNA, thereby preventing autoimmune disorders. Interestingly, A-to-I editing can be used not only to correct genomic mutations at the RNA level but also to modulate tumor antigenicity with large therapeutic potential. We highlight recent developments in the field, focusing on cancer and other human diseases.

中文翻译：

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编辑关于疾病发展的 I。

RNA 的腺苷到肌苷 (A-to-I) 编辑导致腺苷脱氨基生成肌苷。肌苷被细胞机器解释为鸟苷，从而改变转录物的编码、折叠、剪接或运输。A-to-I 编辑受到严格监管。改变编辑对人类健康有严重后果，可能导致干扰素病、神经系统疾病和心血管疾病，并影响癌症进展。ADAR1 介导的 RNA 编辑在抗病毒免疫中发挥重要作用，对于区分内源性和病毒性 RNA 至关重要，从而预防自身免疫性疾病。有趣的是，A-to-I 编辑不仅可用于纠正 RNA 水平的基因组突变，还可用于调节具有巨大治疗潜力的肿瘤抗原性。我们强调该领域的最新发展，