An efficient photocatalytic regioselective difluoroalkylation of 8‐aminoquinolines at the C‐5 position via a debrominative coupling reaction with difluoromethyl bromides has been developed. A series of 8‐aminoquinolines amides proved to be tolerated for this transformation, affording a variety of 5‐difluoromethylated quinoline derivatives in moderate to excellent yields. This protocol was highlighted by its readily available starting materials, wide functional group tolerance, operational simplicity, and mild conditions.

中文翻译：

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通过功能化二氟甲基溴的脱溴偶联将8-氨基喹啉的可见光诱导的远程CH H二氟烷基化

通过与二氟甲基溴的脱溴偶联反应，已开发出一种在C-5位的8-氨基喹啉有效的光催化区域选择性二氟烷基化方法。事实证明，这种转化可以耐受一系列8-氨基喹啉酰胺，这些衍生物以中等到极好的收率提供了各种5-二氟甲基化喹啉衍生物。易于使用的起始材料，宽泛的官能团耐受性，操作简便性和温和的条件突显了该方案。