The Neuronal Ceroid Lipofuscinoses are a group of severe and progressive neurodegenerative disorders, which generally present during childhood. With new treatments emerging on the horizon, there is a growing need to understand the specific disease mechanisms as well as identify prospective biomarkers for use to stratify patients and monitor treatment. The use of Omics technologies to NCLs has the potential to address this need. We discuss the recent use and outcomes of Omics to various forms of NCL including identification of interactomes, affected biological pathways and potential biomarker candidates. We also identify common pathways affected in NCL across the reviewed studies.

神经元类固醇脂褐藻糖是一组严重和进行性神经退行性疾病，通常在儿童时期出现。随着新疗法的出现，人们越来越需要了解具体的疾病机制以及确定用于对患者进行分层和监测治疗的前瞻性生物标志物。在NCL上使用Omics技术可以解决这一需求。我们讨论了Omics对各种形式的NCL的近期使用和结果，包括相互作用组的鉴定，受影响的生物学途径和潜在的生物标志物候选物。我们还确定了在整个综述研究中NCL受到影响的常见途径。