Stem cells are a sub population of cell types that form the foundation of our body, and have the potential to replicate, replenish and repair limitlessly to maintain the tissue and organ homeostasis. Increased lifetime and frequent replication set them vulnerable for both exogenous and endogenous agents-induced DNA damage compared to normal cells. To counter these damages and preserve genetic information, stem cells have evolved with various DNA damage response and repair mechanisms. Furthermore, upon experiencing irreparable DNA damage, stem cells mostly prefer early senescence or apoptosis to avoid the accumulation of damages. However, the failure of these mechanisms leads to various diseases, including cancer. Especially, given the importance of stem cells in early development, DNA repair deficiency in stem cells leads to various disabilities like developmental delay, premature aging, sensitivity to DNA damaging agents, degenerative diseases, etc. In this review, we have summarized the recent update about how DNA repair mechanisms are regulated in stem cells and their association with disease progression and pathogenesis.

中文翻译：

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DNA修复干细胞维护，健康和疾病中的保真度。

干细胞是构成我们身体基础的细胞类型的亚群，具有无限复制，补充和修复以维持组织和器官稳态的潜力。与正常细胞相比，增加的寿命和频繁的复制使它们易受外源性和内源性试剂诱导的DNA损伤。为了对抗这些损害并保存遗传信息，干细胞已经进化出具有各种DNA损害反应和修复机制的细胞。此外，一旦遭受不可挽回的DNA损伤，干细胞通常更喜欢早期衰老或凋亡，以避免损伤的积累。但是，这些机制的失败会导致各种疾病，包括癌症。特别是，鉴于干细胞在早期发育中的重要性，