Acyl carrier protein (ACP) is a principal partner in the cytosolic and mitochondrial fatty acid synthesis (FAS) pathways. The active form holo-ACP serves as FAS platform, using its 4'-phosphopantetheine group to present covalently attached FAS intermediates to the enzymes responsible for the acyl chain elongation process. Mitochondrial unacylated holo-ACP is a component of mammalian mitoribosomes, and acylated ACP species participate as interaction partners in several ACP-LYRM (leucine-tyrosine-arginine motif)-protein heterodimers that act either as assembly factors or subunits of the electron transport chain and Fe-S cluster assembly complexes. Moreover, octanoyl-ACP provides the C8 backbone for endogenous lipoic acid synthesis. Accumulating evidence suggests that mtFAS-generated acyl-ACPs act as signaling molecules in an intramitochondrial metabolic state sensing circuit, coordinating mitochondrial acetyl-CoA levels with mitochondrial respiration, Fe-S cluster biogenesis and protein lipoylation.

中文翻译：

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线粒体酰基载体蛋白（ACP）位于代谢状态感应和线粒体功能的界面。

酰基载体蛋白（ACP）是胞质和线粒体脂肪酸合成（FAS）途径的主要伙伴。活性形式holo-ACP充当FAS平台，利用其4'-磷酸泛汀基团将共价连接的FAS中间体呈递给负责酰基链延长过程的酶。线粒体未酰化的全环ACP是哺乳动物线粒体的一个组成部分，并且酰化的ACP物种作为相互作用的伴侣参与了几种ACP-LYRM（亮氨酸-酪氨酸-精氨酸基序）-蛋白质异二聚体，这些异二聚体既可以作为电子运输链的装配因子，也可以作为亚基。 Fe-S簇组装配合物。此外，辛酰基-ACP为内生硫辛酸合成提供了C8骨架。