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Physiological status of silver carp (Hypophthalmichthys molitrix) in the Illinois River: An assessment of fish at the leading edge of the invasion front.
Comparative Biochemistry and Physiology D: Genomics & Proteomics ( IF 3 ) Pub Date : 2019-07-29 , DOI: 10.1016/j.cbd.2019.100614
Jennifer D Jeffrey 1 , Ken M Jeffries 2 , Cory D Suski 1
Affiliation  

Silver carp (Hypophthalmichthys molitrix) are invasive to North America, and their range has expanded within the Mississippi River Basin, seemingly unchecked, since their introduction in the late 1970s, with the exception of the upper reaches of the Illinois River. With the imminent threat of their movement into the Great Lakes, the goal of the present study was to assess whether differences in the physiological status between silver carp at the leading edge of their invasion front and core population sites could explain their lack of expansion upstream toward Lake Michigan over the past decade. A transcriptomic approach using RNA sequencing and analysis of plasma variables were used to quantify differences among fish at the leading edge and two downstream core population sites. Leading-edge fish exhibited upregulation of genes associated with xenobiotic defense (e.g., ATP-binding cassette C1 [abcc1], abcc2, abcc6), decreased cell integrity (i.e., macroautophagy and apoptosis; autophagy-related protein 9A [atg9a], caspase 3b [casp3b]), and cholesterol metabolism (e.g., abca1, apolipoprotein A1 [apoa1], sterol O-acyltransferase [soat1]) and downregulation of genes associated with DNA repair (e.g., tumor suppressor p53-binding protein 1 [tp53bp1]) compared to core population sites. Transcriptomic profiles of leading-edge fish were consistent with fish inhabiting a polluted environment and suggest that poorer water quality conditions upstream of the leading edge may represent a non-permanent barrier to silver carp range expansion. The present study provides potential molecular targets for monitoring the physiological status of silver carp over time and in response to future improvements in water quality upstream of their leading edge.

中文翻译:

伊利诺伊河of鱼的生理状况:对入侵前沿前沿鱼类的评估。

鱼(Hypophthalmichthys molitrix)入侵北美,自1970年代后期引入伊利诺伊河上游以来,其范围在密西西比河流域内不断扩大,似乎不受限制。由于它们迁移到五大湖中的迫在眉睫的威胁,本研究的目的是评估在入侵前沿前沿的edge鱼与核心种群地点之间的生理状况差异是否可以解释其向上游缺乏扩展的原因。过去十年的密歇根湖。使用RNA测序和血浆变量分析的转录组学方法可量化前缘和两个下游核心种群位点鱼类之间的差异。前沿鱼类表现出与异种生物防御相关的基因上调(例如,ATP结合盒C1 [abcc1],abcc2,abcc6),细胞完整性降低(即,巨噬细胞吞噬和凋亡;自噬相关蛋白9A [atg9a],胱天蛋白酶3b) [casp3b])和胆固醇代谢(例如abca1,载脂蛋白A1 [apoa1],固醇O-酰基转移酶[soat1])和与DNA修复相关的基因下调(例如肿瘤抑制p53结合蛋白1 [tp53bp1])进行比较到核心人口场所。前沿鱼类的转录组谱与栖息在污染环境中的鱼类一致,表明前沿上游水质较差的状况可能代表了silver鱼范围扩展的永久性障碍。
更新日期:2019-07-29
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