Two new azaphilone derivatives, comazaphilones G and H (1 and 2), together with eight known analogues (3-10), were isolated from an endophytic fungus Penicillium variabile. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1, 2 and 4-10 were tested their nitric oxide inhibitory activities in lipopolysaccharide-activated RAW 264.7 macrophage cells. Compounds 1, 2 and 4-9 showed significant nitric oxide inhibitory activities with IC50 values ranged from 4.35 ± 0.05 to 40.52 ± 0.47 μM.

中文翻译：

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来自可变青霉（Penicillium v​​ariabile）的新氮杂苯醌，这是一种来自乌头草（Aconitum vilmorinianum）根的真菌内生菌。

从内生真菌变异青霉中分离出了两种新的氮杂苯甲酮衍生物，即comazaphilones G和H（1和2），以及八种已知的类似物（3-10）。它们的结构是在广泛的光谱分析的基础上建立的。测试了化合物1、2和4-10在脂多糖激活的RAW 264.7巨噬细胞中的一氧化氮抑制活性。化合物1、2和4-9表现出显着的一氧化氮抑制活性，IC50值范围为4.35±0.05至40.52±0.47μM。