This review summarizes the carcinogenic mechanisms for 109 Group 1 human carcinogens identified as causes of human cancer through Volume 106 of the IARC Monographs. The International Agency for Research on Cancer (IARC) evaluates human, experimental and mechanistic evidence on agents suspected of inducing cancer in humans, using a well-established weight of evidence approach. The monographs provide detailed mechanistic information about all carcinogens. Carcinogens with closely similar mechanisms of action (e.g. agents emitting alpha particles) were combined into groups for the review. A narrative synopsis of the mechanistic profiles for the 86 carcinogens or carcinogen groups is presented, based primarily on information in the IARC monographs, supplemented with a non-systematic review. Most carcinogens included a genotoxic mechanism.

中文翻译：

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人类致癌物的生物学机制概述。

这篇综述总结了通过IARC专着第106卷确定的109组第1类人类致癌物的致癌机制。国际癌症研究机构（IARC）使用一种公认的证据权重方法，评估了关于怀疑可诱发人类癌症的药物的人类，实验和机制证据。这些专着提供了有关所有致癌物的详细机理信息。具有相似作用机制的致癌物（例如，释放α粒子的物质）被归类为一组。主要根据IARC专着中的信息并辅以非系统性综述，介绍了86种致癌物或致癌物组的机理概况。大多数致癌物都具有遗传毒性机制。