BACKGROUND AND AIMS Fetal alcohol spectrum disorder (FASD) is a preventable condition that imposes a significant financial burden on societies. Funding of FASD prevention is a small portion of the total expenditures associated with FASD. This paper aimed to review the literature on the costs of and savings from prevention of FASD and present a model for the US and Canada of projected savings based on expansion of existing evidence-based prevention models. METHODS A systematic review of published literature on the cost of FASD prevention was conducted and experts in the field were interviewed. Studies that reported the cost of primary prevention of FASD were eligible for further consideration. RESULTS Applying evidenced-based prevention programs to women at highest risk to have a future child with FASD reduces the cost of prevention of one case by $1,215,600 in the US. This is a 62 fold cost savings compared with the cost of preventing one case among all women who drink. CONCLUSION Expansion of risk-based prevention strategies for fetal alcohol spectrum disorder in the US and Canada would be economically efficient and worthwhile investment for society.

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胎儿酒精谱系障碍：美国和加拿大预防成本和节省的系统回顾

背景和目的 胎儿酒精谱系障碍 (FASD) 是一种可预防的疾病，给社会带来了巨大的经济负担。FASD 预防资金占与 FASD 相关的总支出的一小部分。本文旨在回顾有关预防 FASD 的成本和节省的文献，并在扩展现有循证预防模型的基础上，为美国和加拿大提供预测节省的模型。方法 对已发表的关于 FASD 预防成本的文献进行系统审查，并采访了该领域的专家。报告 FASD 一级预防成本的研究有资格进一步考虑。结果 在美国，将循证预防计划应用于未来生育 FASD 孩子的风险最高的妇女，可将一例病例的预防成本降低 1,215,600 美元。与在所有饮酒的女性中预防一个病例的成本相比，这节省了 62 倍的成本。结论 在美国和加拿大扩大基于风险的胎儿酒精谱系障碍预防策略将是经济有效的，对社会来说是值得的投资。