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New insight into sortilin in controlling lipid metabolism and the risk of atherogenesis
Biological Reviews ( IF 10.0 ) Pub Date : 2019-10-18 , DOI: 10.1111/brv.12561
Xin Su 1 , Daoquan Peng 1
Affiliation  

Dyslipidemia, including increased plasma levels of low‐density lipoprotein cholesterol (LDL‐C), very low‐density lipoprotein cholesterol and triglyceride, and decreased plasma levels of high‐density lipoprotein cholesterol, has been considered a key factor associated with a series of health problems grouped together as metabolic syndrome. Worldwide, dyslipidemia has become a pressing issue, together with the rising prevalence of metabolic syndrome and cardiovascular disease (CVD). Recently, multiple genome‐wide association studies and experimental analyses have been used to assess the underlying genetic basis of lipid metabolism and to identify novel gene loci that contribute to the alterations in lipid levels. The results have demonstrated that sortilin, which is encoded by SORT1, plays an important role in modulating the level of LDL‐C and the risk of CVD. Herein, we summarize the current understanding of the role of sortilin in the pathogenesis of dyslipidemia and atherosclerosis. Furthermore, we provide new insights into the potential mechanisms by which sortilin affects lipid metabolism in hepatocytes, adipocytes, and macrophages.

中文翻译:

分拣蛋白控制脂质代谢和动脉粥样硬化风险的新见解

血脂异常,包括血浆低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇和甘油三酯水平升高,以及血浆高密度脂蛋白胆固醇水平降低,被认为是与一系列健康相关的关键因素问题归为代谢综合症。在世界范围内,随着代谢综合征和心血管疾病 (CVD) 患病率的上升,血脂异常已成为一个紧迫的问题。最近,多项全基因组关联研究和实验分析已被用于评估脂质代谢的潜在遗传基础,并确定有助于脂质水平改变的新基因位点。结果表明,由 SORT1 编码的 sortilin,在调节 LDL-C 水平和 CVD 风险方面起着重要作用。在此,我们总结了目前对sortilin在血脂异常和动脉粥样硬化发病机制中作用的认识。此外,我们对 sortilin 影响肝细胞、脂肪细胞和巨噬细胞脂质代谢的潜在机制提供了新的见解。
更新日期:2019-10-18
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