The treatment of infected, long-term, non-healing, complicated wounds of the skin and mucosa, trophic ulcers, pressure sores and ulcers of diabetic feet represents a serious problem, especially in the case of resistant and multi-resistant pathogens. Antibacterial photodynamic therapy can be a promising method of local infected foci treatment of such diseases. This work is devoted to the study of the possibility of photodynamic inactivation (PDI) of Pseudomonas aeruginosa bacteria in the form of biofilms with the help of new polycationic photosensitizers (PSs) based on octacationic phthalocyanine and tetra- and octabacteriochlorins (ZnPcChol 8 , (3-PyBrE) 4 BCBr 4 and (3-PyEPy) 4 BCBr 8 ). More specifically, this work aims to clarify the role of light irradiation in PDI with the participation of new PSs, which has not been fully studied, especially with respect to the comparison of different PS types.

中文翻译：

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使用新型聚阳离子光敏剂对铜绿假单胞菌细菌生物膜进行光动力灭活

感染的，长期的，不能治愈的，复杂的皮肤和粘膜伤口，营养性溃疡，褥疮和糖尿病性足溃疡的治疗是一个严重的问题，特别是在耐药和多耐药病原体的情况下。抗菌光动力疗法可能是局部感染病灶治疗此类疾病的一种有前途的方法。这项工作致力于研究基于八酸酞菁和四，八细菌氯素的新型多阳离子光敏剂（PSs），以生物膜形式对铜绿假单胞菌细菌进行光动力灭活（PDI）的可能性（ZnPcChol 8，（3 -PyBrE）4 BCBr 4和（3-PyEPy）4 BCBr 8）。更具体地说，这项工作旨在阐明在新的PS参与下PDI中光辐照的作用，但尚未进行充分研究，