Material and energy results were used in a techno-economic model to analyze the effect of different parameters and configurations on the economics of the process of a liquid hot water pretreated switchgrass (Panicum virgatum L.) biorefinery. Previous experimental results for switchgrass composition and its cellulose enzymatic hydrolysis at different high solids content and enzyme dosages were used in order to obtain a more realistic analysis. The minimum ethanol selling price (MESP) obtained for a facility that produces only ethanol and electricity was within the expected price range for advanced alcohol fuels and could compete with oil prices above $100 per barrel. The MESP was lower for a biorefinery scenario that produces furfural, acetic acid, and formic acid as high-value co-products. The MESP was sensitive to plant size and to switchgrass composition. Enzyme dosage, solids content, and hydrolysis and fermentation efficiencies were the operating parameters with a higher impact on the MESP. Experimental results were combined with the techno-economic models to find correlations between the MESP, and solids content and enzyme dosage. The conditions necessary for a high efficiency of hydrolysis and glucose concentration are not necessarily those that produce an economic optimum (lower cost). The enzyme dosage that minimizes MESP is not always associated with the optimal hydrolysis efficiency (e.g., 95%). The best conditions identified through optimization were an enzyme dosage of 37 mg_protein g_glucan⁻¹ and a solids content of 21%, leading to the lowest MESP of $0.84 L^-1 (for an enzyme cost of $4.5 kg_protein ⁻¹).

将材料和能量的结果用于技术经济模型中，以分析不同参数和配置对液态热水预处理柳枝（（Panicum virgatum）的经济影响。L.）生物精炼厂。为了获得更切合实际的分析结果，使用了柳枝composition组合物及其纤维素酶在不同高固含量和不同酶用量下的先前实验结果。仅生产乙醇和电力的工厂获得的最低乙醇销售价格（MESP）在先进酒精燃料的预期价格范围内，并且可以与每桶100美元以上的油价竞争。对于生产糠醛，乙酸和甲酸作为高价值副产品的生物精炼厂而言，MESP较低。MESP对植物大小和柳枝composition组成敏感。酶的用量，固体含量以及水解和发酵效率是对MESP有较高影响的操作参数。将实验结果与技术经济模型相结合，以找出MESP与固体含量和酶用量之间的相关性。高效水解和葡萄糖浓缩所需的条件不一定是产生经济最佳（较低成本）的条件。使MESP最小化的酶剂量并不总是与最佳水解效率相关（例如95％）。通过优化确定的最佳条件是37 mg的酶剂量_蛋白质g_葡聚糖^-1和固体含量为21％，导致最低的MESP为$ 0.84 L ^-1（酶成本为$ 4.5 kg_蛋白质 ^-1）。