Objective:

In schizophrenia, the anterior hippocampus is hyperactive and shows reduced task-related recruitment, but the relationship between these two findings is unclear. The authors tested the hypothesis that hyperactivity impairs recruitment of the anterior hippocampus during scene processing.

Methods:

Functional MRI data from 45 early-psychosis patients and 35 demographically matched healthy control subjects were analyzed using a block-design 1-back scene-processing task. Hippocampal activation in response to scenes and faces compared with scrambled images was measured. In a subset of 20 early-psychosis patients and 31 healthy control subjects, baseline hippocampal activity using cerebral blood volume (CBV) mapping was measured. Correlation analyses were used to examine the association between baseline hippocampal activity and task-related hippocampal activation.

Results:

Activation of the anterior hippocampus was significantly reduced and CBV in the anterior hippocampus was significantly increased in the early stages of psychosis. Increased CBV in early-psychosis patients was inversely correlated with task-related activation during scene processing in the anterior hippocampus.

Conclusions:

Anterior hippocampal hyperactivity in early-psychosis patients appears to limit effective recruitment of this region during task performance. These findings provide novel support for the anterior hippocampus as a therapeutic target in the treatment of cognitive deficits in psychosis.

中文翻译：

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早期精神病患者的过度活跃和海马前部激活减少

客观的：

在精神分裂症中，海马前部活动亢进并显示出与任务相关的募集减少，但是这两个发现之间的关系尚不清楚。作者检验了以下假设：运动过度会削弱场景处理过程中前海马的募集。

方法：

使用分块设计的1向后场景处理任务分析了来自45位早期精神病患者和35位人口统计学匹配的健康对照受试者的MRI功能数据。测量了海马对场景和面部的反应，并与加扰后的图像进行了比较。在20例早期精神病患者和31例健康对照者的子集中，使用脑血容量（CBV）作图测量了基线海马活动。相关分析用于检查基线海马活动与任务相关的海马激活之间的关联。

结果：

在精神病的早期阶段，前海马的激活显着减少，前海马的CBV显着增加。早期精神病患者的CBV升高与前海马场景处理过程中与任务相关的激活呈负相关。

结论：

早期精神病患者的前海马活动亢进似乎限制了任务执行过程中该区域的有效募集。这些发现为作为治疗精神病认知缺陷的治疗目标的海马前体提供了新颖的支持。